Abstract :Pulmonary mucormycosis is an opportunistic invasive fungal infection due to the inhalation of orders Mucorales, class Zygomycetes into the bronchioles and alveoli. It commonly occurs in patients with immunocompromised conditions, particularly in chemotherapy-induced neutropenia associated with hematologic malignancy. Pulmonary mucormycosis is often rapidly progressive and fatal, however, it can also perform as subacute or chronic courses. In this article, we present a case of subacute pulmonary mucormycosis in an elderly Chinese diabetic patient, mimicking the lung cancer, obtaining definite pathologic diagnosis through CT-guide transthoracic needle biopsy followed by negative result trough flexible bronchoscopy examination.